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Data-driven identification of endophenotypes of Alzheimer's disease progression: implications for clinical trials and therapeutic interventions.

Nophar GeifmanRichard E KennedyLon S SchneiderIain BuchanRoberta Diaz Brinton
Published in: Alzheimer's research & therapy (2018)
Our results, 'learned' from clinical data, indicate the existence of at least three subgroups of Alzheimer's patients, each demonstrating a different trajectory of disease progression. This hypothesis-generating approach has detected distinct AD subgroups that may prove to be discrete endophenotypes linked to specific aetiologies. These findings could enable stratification within a clinical trial or study context, which may help identify new targets for intervention and guide better care.
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