Cytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus Pleosporales sp. NBUF144.
Jing ZhouHairong ZhangJing YeXingxin WuWeiyi WangHouwen LinXiaojun YanJ Enrico H LazaroTingting WangC Benjamin NamanShan HePublished in: Marine drugs (2021)
Two new polyketide natural products, globosuxanthone F (1), and 2'-hydroxy bisdechlorogeodin (2), were isolated from the fungus Pleosporales sp. NBUF144, which was derived from a 62 m deep Chalinidae family sponge together with four known metabolites, 3,4-dihydroglobosuxanthone A (3), 8-hydroxy-3-methylxanthone-1-carboxylate (4), crosphaeropsone C (5), and 4-megastigmen-3,9-dione (6). The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR and high-resolution electrospray ionization mass spectra (HRESIMS) data. The absolute configuration of 1 was further established by single-crystal X-ray diffraction studies. Compounds 1-5 were evaluated for cytotoxicity towards CCRF-CEM human acute lymphatic leukemia cells, and it was found that 1 had an IC50 value of 0.46 µM.
Keyphrases
- high resolution
- ms ms
- induced apoptosis
- endothelial cells
- mass spectrometry
- liver failure
- cell cycle arrest
- molecular docking
- lymph node
- acute myeloid leukemia
- respiratory failure
- induced pluripotent stem cells
- electronic health record
- big data
- magnetic resonance
- density functional theory
- magnetic resonance imaging
- signaling pathway
- pluripotent stem cells
- cell proliferation
- computed tomography
- machine learning
- data analysis
- intensive care unit
- artificial intelligence
- acute respiratory distress syndrome
- dual energy
- mechanical ventilation