Protective Biomolecular Mechanisms of Glutathione Sodium Salt in Ischemia-Reperfusion Injury in Patients with Acute Coronary Syndrome-ST-Elevation Myocardial Infarction.
Alessio ArriviFrancesco BarillàRoberto CarnevaleMartina SordiGiacomo PucciGaetano TanzilliFrancesca Romana PrandiEnrico MangieriPublished in: Cells (2022)
Ischemia-Reperfusion Injury (IRI) is responsible for adverse outcomes in patients with ST-Elevation Myocardial Infarction (STEMI). Oxidative stress, resulting from the production of Reactive Oxygen Species (ROS) and low availability of Glutathione (GSH), are the two main mediators of IRI. The effectiveness of exogenous antioxidant therapy in this scenario is still debated, since the encouraging results obtained in animal models have not been fully reproduced in clinical studies. In this review we focus on the role of GSH, specifically on the biomolecular mechanisms that preserve myocardial cells from damage due to reperfusion. In this regard, we provide an extensive discussion about GSH intrinsic antioxidant properties, its current applications in clinical practice, and the future perspectives.
Keyphrases
- st elevation myocardial infarction
- oxidative stress
- ischemia reperfusion injury
- reactive oxygen species
- percutaneous coronary intervention
- fluorescent probe
- dna damage
- clinical practice
- acute myocardial infarction
- diabetic rats
- induced apoptosis
- st segment elevation myocardial infarction
- randomized controlled trial
- acute coronary syndrome
- systematic review
- coronary artery disease
- left ventricular
- cell death
- cerebral ischemia
- anti inflammatory
- acute ischemic stroke
- stem cells
- subarachnoid hemorrhage
- cell therapy
- heart failure
- heat shock
- smoking cessation