Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension.
Haiyang TangAkash GuptaSeth A MorrisroeChanglei BaoTae-Hwi Schwantes-AnGeetanjali GuptaShuxin LiangYanan SunAiai ChuAng LuoVenkateswaran Ramamoorthi ElangovanShreya SangamYinan ShiSamisubbu R NaiduJia-Rong JhengSultan Ciftci-YilmazNoel A WarfelLouise HeckerSumegha MitraAnna W ColemanKatie A LutzMichael W PauciuloYen-Chun LaiAli JavaheriRohan DharmakumarWen-Hui WuDaniel P FlahertyJason H KarnesSandra Breuils-BonnetOlivier BoucheratSebastien BonnetJason X-J YuanJeffrey R JacobsonJulio D DuarteWilliam C NicholsJoe G N GarciaAnkit A DesaiPublished in: Circulation (2024)
Our findings suggest that UCHL1 deficiency results in PAH attenuation by means of reduced AKT1, highlighting a novel therapeutic pathway in PAH.