Daniel P Flaherty (Daniel Flaherty)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 36

Top Venues

Journal of medicinal chemistry

Journal of enzyme inhibition and medicinal chemistry

Circulation

ACS medicinal chemistry letters

Purdue University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Purdue University Jul 01 2015

United States

Assistant Professor :: Medicinal Chemistry and Molecular Pharmacology

University of Kansas Jan 31 2014 - Jul 01 2015

United States

Research Assistant Professor :: Higuchi Biosciences Center

University of Kansas Jul 01 2010 - Jan 29 2014

United States

Postdoctoral Research Associate :: Medicinal Chemistry

Publications

Alessandro Bonardi, Alessio Nocentini, Simone Giovannuzzi, Niccolò Paoletti, Andrea Ammara, Silvia Bua, Nader S Abutaleb, Abdallah S Abdelsattar, Clemente Capasso, Paola Gratteri, Daniel P Flaherty, Mohamed N Seleem, Claudiu T Supuran
Development of Penicillin-Based Carbonic Anhydrase Inhibitors Targeting Multidrug-Resistant Neisseria gonorrhoeae . Journal of medicinal chemistry (2024)
Haiyang Tang, Akash Gupta, Seth A Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Geetanjali Gupta, Shuxin Liang, Yanan Sun, Aiai Chu, Ang Luo, Venkateswaran Ramamoorthi Elangovan, Shreya Sangam, Yinan Shi, Samisubbu R Naidu, Jia-Rong Jheng, Sultan Ciftci-Yilmaz, Noel A Warfel, Louise Hecker, Sumegha Mitra, Anna W Coleman, Katie A Lutz, Michael W Pauciulo, Yen-Chun Lai, Ali Javaheri, Rohan Dharmakumar, Wen-Hui Wu, Daniel P Flaherty, Jason H Karnes, Sandra Breuils-Bonnet, Olivier Boucherat, Sebastien Bonnet, Jason X-J Yuan, Jeffrey R Jacobson, Julio D Duarte, William C Nichols, Joe G N Garcia, Ankit A Desai
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension. Circulation (2024)
Ryan D Imhoff, Rishi Patel, Muhammad Hassan Safdar, Hannah B L Jones, Adan Pinto-Fernandez, Iolanda Vendrell, Hao Chen, Christine S Muli, Aaron D Krabill, Benedikt Mathias Kessler, Michael K Wendt, Chittaranjan Das, Daniel P Flaherty
Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1. Journal of medicinal chemistry (2024)
Alessandro Bonardi, Alessio Nocentini, Simone Giovannuzzi, Niccolò Paoletti, Andrea Ammara, Silvia Bua, Nader S Abutaleb, Abdallah S Abdelsattar, Clemente Capasso, Paola Gratteri, Daniel P Flaherty, Mohamed N Seleem, Claudiu T Supuran
Development of Penicillin-Based Carbonic Anhydrase Inhibitors Targeting Multidrug-Resistant Neisseria gonorrhoeae . Journal of medicinal chemistry 67 (11) (2024)
Ryan D Imhoff, Rishi Patel, Muhammad Hassan Safdar, Hannah B L Jones, Adan Pinto-Fernandez, Iolanda Vendrell, Hao Chen, Christine S Muli, Aaron D Krabill, Benedikt Mathias Kessler, Michael K Wendt, Chittaranjan Das, Daniel P Flaherty
Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1. Journal of medicinal chemistry 67 (6) (2024)
Molly S Youse, Nader S Abutaleb, Alessio Nocentini, Abdallah S Abdelsattar, Farman Ali, Claudiu T Supuran, Mohamed N Seleem, Daniel P Flaherty
Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae . Journal of medicinal chemistry (2024)
Ryan D Imhoff, Rishi Patel, Muhammad Hassan Safdar, Hannah B L Jones, Adan Pinto-Fernandez, Iolanda Vendrell, Hao Chen, Christine S Muli, Aaron D Krabill, Benedikt Mathias Kessler, Michael K Wendt, Chittaranjan Das, Daniel P Flaherty
Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1. Journal of medicinal chemistry 67 (6) (2024)
Haiyang Tang, Akash Gupta, Seth A Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Geetanjali Gupta, Shuxin Liang, Yanan Sun, Aiai Chu, Ang Luo, Venkateswaran Ramamoorthi Elangovan, Shreya Sangam, Yinan Shi, Samisubbu R Naidu, Jia-Rong Jheng, Sultan Ciftci-Yilmaz, Noel A Warfel, Louise Hecker, Sumegha Mitra, Anna W Coleman, Katie A Lutz, Michael W Pauciulo, Yen-Chun Lai, Ali Javaheri, Rohan Dharmakumar, Wen-Hui Wu, Daniel P Flaherty, Jason H Karnes, Sandra Breuils-Bonnet, Olivier Boucherat, Sebastien Bonnet, Jason X-J Yuan, Jeffrey R Jacobson, Julio D Duarte, William C Nichols, Joe G N Garcia, Ankit A Desai
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension. Circulation (2024)
Alessandro Bonardi, Alessio Nocentini, Simone Giovannuzzi, Niccolò Paoletti, Andrea Ammara, Silvia Bua, Nader S Abutaleb, Abdallah S Abdelsattar, Clemente Capasso, Paola Gratteri, Daniel P Flaherty, Mohamed N Seleem, Claudiu T Supuran
Development of Penicillin-Based Carbonic Anhydrase Inhibitors Targeting Multidrug-Resistant Neisseria gonorrhoeae . Journal of medicinal chemistry (2024)
Haiyang Tang, Akash Gupta, Seth A Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Geetanjali Gupta, Shuxin Liang, Yanan Sun, Aiai Chu, Ang Luo, Venkateswaran Ramamoorthi Elangovan, Shreya Sangam, Yinan Shi, Samisubbu R Naidu, Jia-Rong Jheng, Sultan Ciftci-Yilmaz, Noel A Warfel, Louise Hecker, Sumegha Mitra, Anna W Coleman, Katie A Lutz, Michael W Pauciulo, Yen-Chun Lai, Ali Javaheri, Rohan Dharmakumar, Wen-Hui Wu, Daniel P Flaherty, Jason H Karnes, Sandra Breuils-Bonnet, Olivier Boucherat, Sebastien Bonnet, Jason X-J Yuan, Jeffrey R Jacobson, Julio D Duarte, William C Nichols, Joe G N Garcia, Ankit A Desai
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension. Circulation 150 (4) (2024)
Haiyang Tang, Akash Gupta, Seth A Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Geetanjali Gupta, Shuxin Liang, Yanan Sun, Aiai Chu, Ang Luo, Venkateswaran Ramamoorthi Elangovan, Shreya Sangam, Yinan Shi, Samisubbu R Naidu, Jia-Rong Jheng, Sultan Ciftci-Yilmaz, Noel A Warfel, Louise Hecker, Sumegha Mitra, Anna W Coleman, Katie A Lutz, Michael W Pauciulo, Yen-Chun Lai, Ali Javaheri, Rohan Dharmakumar, Wen-Hui Wu, Daniel P Flaherty, Jason H Karnes, Sandra Breuils-Bonnet, Olivier Boucherat, Sebastien Bonnet, Jason X-J Yuan, Jeffrey R Jacobson, Julio D Duarte, William C Nichols, Joe G N Garcia, Ankit A Desai
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension. Circulation 150 (4) (2024)
Simone Giovannuzzi, Anil Kumar Marapaka, Nader S Abutaleb, Fabrizio Carta, Hsin-Wen Liang, Alessio Nocentini, Luigi Pisano, Mohamed N Seleem, Daniel P Flaherty, Claudiu T Supuran
Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates. Journal of enzyme inhibition and medicinal chemistry 38 (1) (2023)
Nader S Abutaleb, Annadka Shrinidhi, Aloka B Bandara, Mohamed N Seleem, Daniel P Flaherty
Evaluation of 1,3,4-Thiadiazole Carbonic Anhydrase Inhibitors for Gut Decolonization of Vancomycin-Resistant Enterococci. ACS medicinal chemistry letters 14 (4) (2023)
Mikaeel Young, Michaelle Chojnacki, Catlyn Blanchard, Xufeng Cao, William L Johnson, Daniel P Flaherty, Paul M Dunman
Genetic Determinants of Acinetobacter baumannii Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance. Antibiotics (Basel, Switzerland) 12 (7) (2023)
Anil Kumar Marapaka, Alessio Nocentini, Molly S Youse, Weiwei An, Katrina J Holly, Chittaranjan Das, Ravi Yadav, Mohamed N Seleem, Claudiu T Supuran, Daniel P Flaherty
Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae α-Carbonic Anhydrase. ACS medicinal chemistry letters 14 (1) (2022)
Simone Giovannuzzi, Chad S Hewitt, Alessio Nocentini, Clemente Capasso, Daniel P Flaherty, Claudiu T Supuran
Coumarins effectively inhibit bacterial α-carbonic anhydrases. Journal of enzyme inhibition and medicinal chemistry 37 (1) (2022)
Simone Giovannuzzi, Nader S Abutaleb, Chad S Hewitt, Fabrizio Carta, Alessio Nocentini, Mohamed N Seleem, Daniel P Flaherty, Claudiu T Supuran
Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae . Journal of enzyme inhibition and medicinal chemistry 37 (1) (2022)
Nader S Abutaleb, Ahmed E M Elhassanny, Alessio Nocentini, Chad S Hewitt, Ahmed Elkashif, Bruce R Cooper, Claudiu T Supuran, Mohamed N Seleem, Daniel P Flaherty
Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae . Journal of enzyme inhibition and medicinal chemistry 37 (1) (2022)
Anil Kumar Marapaka, Alessio Nocentini, Molly S Youse, Weiwei An, Katrina J Holly, Chittaranjan Das, Ravi Yadav, Mohamed N Seleem, Claudiu T Supuran, Daniel P Flaherty
Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae α-Carbonic Anhydrase. ACS medicinal chemistry letters 14 (1) (2022)
Simone Giovannuzzi, Chad S Hewitt, Alessio Nocentini, Clemente Capasso, Gabriele Costantino, Daniel P Flaherty, Claudiu T Supuran
Inhibition studies of bacterial α-carbonic anhydrases with phenols. Journal of enzyme inhibition and medicinal chemistry 37 (1) (2022)
Weiwei An, Katrina J Holly, Alessio Nocentini, Ryan D Imhoff, Chad S Hewitt, Nader S Abutaleb, Xufeng Cao, Mohamed N Seleem, Claudiu T Supuran, Daniel P Flaherty
Structure-activity relationship studies for inhibitors for vancomycin-resistant Enterococcus and human carbonic anhydrases. Journal of enzyme inhibition and medicinal chemistry 37 (1) (2022)
Chad S Hewitt, Chittaranjan Das, Daniel P Flaherty
Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3. Biomolecules 12 (1) (2022)
Jason A Scott, Monica Soto-Velasquez, Michael P Hayes, Justin E LaVigne, Heath R Miller, Jatinder Kaur, Karin F K Ejendal, Val J Watts, Daniel P Flaherty
Optimization of a Pyrimidinone Series for Selective Inhibition of Ca 2+ /Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain. Journal of medicinal chemistry 65 (6) (2022)
Alessio Nocentini, Chad S Hewitt, Margaret D Mastrolorenzo, Daniel P Flaherty, Claudiu T Supuran
Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae. Journal of enzyme inhibition and medicinal chemistry 36 (1) (2021)
Michaelle Chojnacki, Xufeng Cao, Daniel P Flaherty, Paul M Dunman
Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against Staphylococcus aureus RnpA. Antibiotics (Basel, Switzerland) 10 (4) (2021)
Michael J Sheedlo, Sebastian Kenny, Ivan S Podkorytov, Kwame Brown, Jia Ma, Shalini Iyer, Chad S Hewitt, Trent Arbough, Oleg Mikhailovskii, Daniel P Flaherty, Mark A Wilson, Nikolai R Skrynnikov, Chittaranjan Das
Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA. Biochemistry 60 (8) (2021)
Chad S Hewitt, Nader S Abutaleb, Ahmed E M Elhassanny, Alessio Nocentini, Xufeng Cao, Devon P Amos, Molly S Youse, Katrina J Holly, Anil Kumar Marapaka, Weiwei An, Jatinder Kaur, Aaron D Krabill, Ahmed Elkashif, Yehia Elgammal, Amanda L Graboski, Claudiu T Supuran, Mohamed N Seleem, Daniel P Flaherty
Structure-Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae. ACS infectious diseases 7 (7) (2021)
Daniel P Flaherty, Mohamed N Seleem, Claudiu T Supuran
Bacterial carbonic anhydrases: underexploited antibacterial therapeutic targets. Future medicinal chemistry 13 (19) (2021)
Sugandha Saboo, Umesh S Kestur, Daniel P Flaherty, Lynne S Taylor
Congruent Release of Drug and Polymer from Amorphous Solid Dispersions: Insights into the Role of Drug-Polymer Hydrogen Bonding, Surface Crystallization, and Glass Transition. Molecular pharmaceutics 17 (4) (2020)
Michaelle Chojnacki, Xufeng Cao, Mikaeel Young, Rebecca N Fritz, Paul M Dunman, Daniel P Flaherty
Optimization of 4-Substituted Benzenesulfonamide Scaffold To Reverse Acinetobacter baumannii Serum-Adaptive Efflux Associated Antibiotic Tolerance. ChemMedChem 15 (18) (2020)
Jatinder Kaur, Xufeng Cao, Nader S Abutaleb, Ahmed Elkashif, Amanda L Graboski, Aaron D Krabill, Ahmed Hassan AbdelKhalek, Weiwei An, Atul Bhardwaj, Mohamed N Seleem, Daniel P Flaherty
Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus. Journal of medicinal chemistry 63 (17) (2020)
Chad S Hewitt, Aaron D Krabill, Chittaranjan Das, Daniel P Flaherty
Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases. Biochemistry 59 (37) (2020)
Aaron D Krabill, Hao Chen, Sajjad Hussain, Chao Feng, Ammara Abdullah, Chittaranjan Das, Uma K Aryal, Carol Beth Post, Michael K Wendt, Paul J Galardy, Daniel P Flaherty
Ubiquitin C-Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine-Based Inhibitor. Chembiochem : a European journal of chemical biology 21 (5) (2019)
Jennifer M Colquhoun, Lisha Ha, Andrew Beckley, Brinkley Meyers, Daniel P Flaherty, Paul M Dunman
Identification of Small Molecule Inhibitors of Staphylococcus aureus RnpA. Antibiotics (Basel, Switzerland) 8 (2) (2019)
Lisha Ha, Jennifer Colquhoun, Nicholas Noinaj, Chittaranjan Das, Paul M Dunman, Daniel P Flaherty
Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus. Acta crystallographica. Section F, Structural biology communications 74 (Pt 10) (2018)
Cecilia Lopez-Sambrooks, Shiteshu Shrimal, Carol Khodier, Daniel P Flaherty, Natalie Rinis, Jonathan C Charest, Ningguo Gao, Peng Zhao, Lance Wells, Timothy A Lewis, Mark A Lehrman, Reid Gilmore, Jennifer E Golden, Joseph N Contessa
Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nature chemical biology 12 (12) (2016)

Daniel P Flaherty.css-eqlu8i{font-size:small;padding-left:4px;} (Daniel Flaherty)

Publication Activity (10 Years)

Top Topics

Top Venues

Daniel P Flaherty (Daniel Flaherty)