Epigenetic dysregulation-mediated COL12A1 upregulation predicts worse outcome in intrahepatic cholangiocarcinoma patients.
Zengwei TangYuan YangQi ZhangTingbo LiangPublished in: Clinical epigenetics (2023)
Promoter hypermethylation-induced miR-424-5p downregulation contributes to COL12A1 upregulation in iCCA. COL12A1 is a promising druggable target for epigenetic therapy of iCCA.
Keyphrases
- dna methylation
- gene expression
- cell proliferation
- end stage renal disease
- signaling pathway
- newly diagnosed
- poor prognosis
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- transcription factor
- high glucose
- stem cells
- diabetic rats
- bone marrow
- mesenchymal stem cells
- endothelial cells
- smoking cessation