Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression.
Bin-Jin HwangLi-Chung TsaoChaitanya R AcharyaTimothy TrotterPankaj AgarwalJunping WeiTao WangXiao-Yi YangGangjun LeiTakuya OsadaHerbert Kim LyerlyMichael A MorseZachary Conrad HartmanPublished in: Journal for immunotherapy of cancer (2022)
These data demonstrate that intratumoral MAVS expression results in local and systemic tumor antigen-specific T cell responses, which could be combined with PD-L1 ICI to permit effective anti-tumor immunotherapy in ICI resistant cancers.