Protective Effect of Melatonin Administration against SARS-CoV-2 Infection: A Systematic Review.

Antonio Molina-CarballoRafael Palacios-LópezAntonio Jerez-CaleroMaría Carmen Augustín-MoralesAhmed AgilAntonio Muñoz-HoyosAntonio Muñoz-Gallego

Published in: Current issues in molecular biology (2021)

: (1) melatonin has anti-inflammatory, antioxidant, immunomodulatory, and Mpro and MMP9 protein-inhibitory activity. (2) It has been shown to have a wide margin of safety. (3) The contributions reviewed make it an effective therapeutic alternative in the treatment of SARS-CoV-2 infection. (4) Further clinical trials are recommended to clearly define the administration protocol.

Keyphrases

anti inflammatory
clinical trial
respiratory syndrome coronavirus
randomized controlled trial
oxidative stress
sars cov
phase ii
binding protein
open label
small molecule
study protocol