Concurrent chemoradiotherapyof different radiation doses and different irradiation fields for locally advanced thoracic esophageal squamous cell carcinoma: A randomized, multicenter, phase III clinical trial.
Jian ZhangMinghao LiKaixian ZhangAnping ZhengGuang LiWei HuangShaoshui ChenXiangming ChenXiaomin LiYanxing ShengXinchen SunLiping LiuXiaowei LiuJie LiJun WangHong GeShucheng YeQingsong PangXianwen ZhangShengbin DaiRichard YuWendong GuMingming DaiGaowa SiqinYunwei HanXiaolin GeXin YuanYongjing YangHaiwen ZhuJuan PuLihua DongXiangdong SunJundong ZhouWeidong MaoFei GaoHaiqun LinHeyi GongTao ZhouZhenjiang LiHongsheng LiZhongtang WangBaosheng LiPublished in: Cancer communications (London, England) (2024)
IFI demonstrated similar treatment efficacy to ENI in CCRT of ESCC. The HD demonstrated improved PFS, but did not significantly improve OS. The dose escalation based on IFI (HD+IFI) showed better therapeutic efficacy than the current recommendation (SD+ENI) and is worth further validation.