SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice.

Domenico SergiFiona M CampbellChristine GrantAmanda C MorrisEva-Maria BachmairChristiane KochFiona H McLeanAifric MullerNigel HoggardBaukje de RoosBegona PorteiroMark V BoekschotenFiona C McGillicuddyDarcy KahnPhyllis NicolJonas BenzlerClaus-Dieter MayerJanice E DrewHelen M RocheMichael MullerRuben NogueirasCarlos DieguezAlexander TupsLynda M Williams

Published in: Genes & nutrition (2018)

These data demonstrate that serpinA3 expression is implicated in nutritionally mediated hypothalamic inflammation.

Keyphrases

high fat diet
insulin resistance
adipose tissue
poor prognosis
high fat diet induced
oxidative stress
electronic health record
genome wide
copy number
big data
type diabetes
skeletal muscle
long non coding rna
gene expression
dna methylation