Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank.

Kimberley M KendallMatthew Bracher-SmithHarry FitzpatrickAmy LynhamElliott ReesValentina Escott-PriceMichael J OwenMichael C O'DonovanJames T R WaltersGeorge Kirov

Published in: The British journal of psychiatry : the journal of mental science (2019)

CNVs implicated in neurodevelopmental disorders, including schizophrenia, are associated with cognitive deficits, even among unaffected individuals. These deficits may be subtle but CNV carriers have significant disadvantages in educational attainment and ability to earn income in adult life.Declaration of interestNone.

Keyphrases

copy number
mitochondrial dna
genome wide
bipolar disorder
traumatic brain injury
dna methylation
physical activity
mental health
cross sectional
gene expression
childhood cancer
young adults