A Novel Swine Model for Inducing Functional Tricuspid Valve Regurgitation.
Dawei LinPeng ZhangYongchao ZhaoWanjiao ChenDandan ChenXiaochun ZhangDaxin ZhouJunbo GePublished in: Journal of cardiovascular translational research (2024)
Functional tricuspid regurgitation (FTR) is the most common TR, although experimental models to effectively study it are scarce; therefore, this study aimed to establish a robust experimental swine model. A swine FTR model was developed using radiofrequency ablation, atrial septostomy, and right atrial volume overload. The baseline and follow-up echocardiography was performed to evaluate the progression FTR and changes in the heart. Autopsy was employed to verify the anatomy of tricuspid valve. One-month post intervention, among the subjects, one (8.3%) exhibited severe FTR, eight (66.7%) exhibited moderate TR, and three (25%) exhibited mild FTR. Each pig developed an atrial septal defect (diameter, 1.5 ± 0.5 cm). The tricuspid annular diameter significantly increased with enlargement of right heart (P < 0.05). No significant difference was found on left heart size and mitral regurgitation. We successfully developed a novel swine FTR model, providing a reliable and effective platform for further research on FTR.
Keyphrases
- aortic valve
- aortic stenosis
- mitral valve
- transcatheter aortic valve replacement
- atrial fibrillation
- left atrial
- heart failure
- radiofrequency ablation
- ejection fraction
- left ventricular
- randomized controlled trial
- computed tomography
- coronary artery disease
- high throughput
- early onset
- pulmonary hypertension
- optic nerve