AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-κB activation in oral squamous cell carcinoma.
Hui-Wen ChiuHsin-Lun LeeHsun-Hua LeeHsiao-Wei LuKent Yu-Hsien LinYuan-Feng LinChe-Hsuan LinPublished in: Journal of translational medicine (2024)
Our data unveil AIM2 as a critical factor for promoting radioresistance, metastasis and PD-L1 expression and as a potential biomarker for predicting ICI effectiveness on the refractory OSCC.
Keyphrases
- signaling pathway
- randomized controlled trial
- electronic health record
- lps induced
- systematic review
- cell proliferation
- pi k akt
- oxidative stress
- big data
- nuclear factor
- dna damage response
- radiation induced
- inflammatory response
- data analysis
- dna damage
- immune response
- toll like receptor
- dna repair
- artificial intelligence