Lipid accumulation in human breast cancer cells injured by iron depletors.
Maida De BortoliElena TavernaElisa MaffioliPatrizia CasaliniFrancesco CrisafiVikas KumarClaudio CacciaDario PolliGabriella TedeschiItalia BongarzonePublished in: Journal of experimental & clinical cancer research : CR (2018)
Iron starvation induces a hypoxia-like program able to scavenge nutrients from the extracellular environment, and cells assume a hypertrophic phenotype. Such survival strategy is accompanied by the ER-dependent massive cytoplasmic vacuolization, mitochondrial dysfunctions, and LD accumulation and then evolves into cell death. LDs containing a greater proportion of unsaturated lipids are released as a consequence of cell death. The consequence of the disruption of iron metabolism in tumour tissue and the effects of LDs on intercellular communication, cancer-inflammation axis, and immunity remain to be explored. Considering the potential benefits, these are crucial subjects for future mechanistic and clinical studies.
Keyphrases
- cell death
- cell cycle arrest
- breast cancer cells
- endothelial cells
- oxidative stress
- iron deficiency
- induced apoptosis
- papillary thyroid
- heavy metals
- quality improvement
- estrogen receptor
- squamous cell carcinoma
- induced pluripotent stem cells
- risk assessment
- signaling pathway
- young adults
- endoplasmic reticulum
- fatty acid