Suppression of VEGFD expression by S-nitrosylation promotes the development of lung adenocarcinoma.

Qiangqiang HeMeiyu QuTingyu ShenYana XuJiahao LuoDan TanChengyun XuMuhammad Qasim BarkatLing-Hui ZengXimei Wu

Published in: Journal of experimental & clinical cancer research : CR (2022)

Low-expression of VEGFD positively correlates with LUAD development. Aberrant S-nitrosylation of VEGFD negates itself to induce the tumorigenesis of LUAD, whereas normal S-nitrosylation of VEGFD is indispensable for its secretion and repression of angiogenesis of LUAD.

Keyphrases

poor prognosis
binding protein
endothelial cells
wound healing