Microglial responses to peripheral type 1 interferon.
Ernest AwYingying ZhangMichael C CarrollPublished in: Journal of neuroinflammation (2020)
Peripheral IFNα induces unique genetic and phenotypic changes in microglia that are largely dependent on direct signalling through microglial IFNAR. The IFNα-induced upregulation of C4b could play important roles in the context of aberrant synaptic pruning in neuropsychiatric disease.