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Microglial responses to peripheral type 1 interferon.

Ernest AwYingying ZhangMichael C Carroll
Published in: Journal of neuroinflammation (2020)
Peripheral IFNα induces unique genetic and phenotypic changes in microglia that are largely dependent on direct signalling through microglial IFNAR. The IFNα-induced upregulation of C4b could play important roles in the context of aberrant synaptic pruning in neuropsychiatric disease.
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