Microglial responses to peripheral type 1 interferon.

Ernest AwYingying ZhangMichael C Carroll

Published in: Journal of neuroinflammation (2020)

Peripheral IFNα induces unique genetic and phenotypic changes in microglia that are largely dependent on direct signalling through microglial IFNAR. The IFNα-induced upregulation of C4b could play important roles in the context of aberrant synaptic pruning in neuropsychiatric disease.

Keyphrases

inflammatory response
dendritic cells
neuropathic pain
lipopolysaccharide induced
lps induced
immune response
chemotherapy induced
high glucose
diabetic rats
poor prognosis
cell proliferation
genome wide
drug induced
copy number
dna methylation
gene expression
long non coding rna