Matrix stiffness-induced upregulation of histone acetyltransferase KAT6A promotes hepatocellular carcinoma progression through regulating SOX2 expression.

Wei ZhaoHuanye MoRunkun LiuTianxiang ChenNan Yang Zhikui Liu

Published in: British journal of cancer (2022)

Our data support the first evidence that KAT6A plays an oncogenic role in HCC through H3K23ac/TRIM24-SOX2 pathway, and represents a promising therapeutic strategy for HCC patients.

Keyphrases

transcription factor
poor prognosis
end stage renal disease
stem cells
newly diagnosed
chronic kidney disease
ejection fraction
dna methylation
machine learning
drug induced
binding protein
artificial intelligence