Circ_0070934 promotes MGAT3 expression and inhibits epithelial-mesenchymal transition in bronchial epithelial cells by sponging miR-199a-5p.

Ziqi DingXinru XiaoLiang FanZhengdao MaoChuang SunNa LiQian Zhang

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2024)

The findings of this study indicate that circ_0070934 may function as a competitive endogenous RNA (ceRNA) of miR-199a-5p, thereby modulating the expression of MGAT3 and impacting the process of EMT in bronchial epithelial cells. These results contribute to the establishment of a theoretical framework for advancing the prevention and treatment strategies for asthma.

Keyphrases

epithelial mesenchymal transition
poor prognosis

long non coding rna
signaling pathway

chronic obstructive pulmonary disease
transforming growth factor

binding protein
cystic fibrosis