PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models.

Ariel L HernandezChristian D YoungLi BianKelsey WeigelKyle NolanBarbara FrederickGangwen HanGuanting HeG Devon TrahanMichael C RudolphKenneth L JonesAyman J OweidaSana D KaramDavid RabenXiao-Jing Wang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

SMAD4 levels are causal in determining sensitivity to PARP inhibition in combination with RT in HNSCCs.

Keyphrases

squamous cell
dna damage
epithelial mesenchymal transition
transforming growth factor
dna repair
endothelial cells
early stage
high grade
induced pluripotent stem cells
pluripotent stem cells
oxidative stress
signaling pathway
wild type