Targeting the activated microenvironment with endosialin (CD248)-directed CAR-T cells ablates perivascular cells to impair tumor growth and metastasis.
Sarah L AshRebecca OrhaHolly MoleMeg Dinesh-KumarSteven P LeeFrances K TurrellClare M IsackePublished in: Journal for immunotherapy of cancer (2024)
cells makes a humanized and optimized E3K CAR a promising candidate for clinical development applicable to a broad range of solid tumor types.