Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition.
Raghav SundarKie Kyon HuangVikrant KumarKalpana RamnarayananDeniz DemirciogluZhisheng HerXuewen OngZul Fazreen Bin Adam IsaManjie XingAngie Lay-Keng TanDavid Wai Meng TaiSu Pin ChooWeiwei ZhaiJia Qi LimMeghna Das ThakurLuciana MolineroEdward ChaMarcella FassoMonica NigerFilippo PietrantonioJeeyun LeeAnand D JeyasekharanAditi QamraRadhika PatnalaArne FabritiusMark De SimoneJoe YeongCedric Chuan Young NgSun Young RhaYukiya NaritaKei MuroYu Amanda GuoAnders Jacobsen SkanderupJimmy Bok Yan SoWei Peng YongQingfeng ChenJonathan GökePatrick Boon-Ooi TanPublished in: Gut (2021)
These findings demonstrate an association between alternate promoter use and the tumour microenvironment, leading to immune evasion and immunotherapy resistance.