Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition.

Raghav SundarKie Kyon HuangVikrant KumarKalpana RamnarayananDeniz DemirciogluZhisheng HerXuewen OngZul Fazreen Bin Adam IsaManjie XingAngie Lay-Keng TanDavid Wai Meng TaiSu Pin ChooWeiwei ZhaiJia Qi LimMeghna Das ThakurLuciana MolineroEdward ChaMarcella FassoMonica NigerFilippo PietrantonioJeeyun LeeAnand D JeyasekharanAditi QamraRadhika PatnalaArne FabritiusMark De SimoneJoe YeongCedric Chuan Young NgSun Young RhaYukiya NaritaKei MuroYu Amanda GuoAnders Jacobsen SkanderupJimmy Bok Yan SoWei Peng YongQingfeng ChenJonathan GökePatrick Boon-Ooi Tan

Published in: Gut (2021)

These findings demonstrate an association between alternate promoter use and the tumour microenvironment, leading to immune evasion and immunotherapy resistance.

Keyphrases

dna methylation
gene expression
transcription factor
crispr cas
stem cells