Belantamab mafodotin in the treatment of relapsed or refractory multiple myeloma.
Semira SheikhEyal LebelSuzanne TrudelPublished in: Future oncology (London, England) (2020)
Multiple myeloma remains an incurable disease, with a large proportion of patients in the relapsed/refractory setting often unable to achieve durable responses. Novel, well-tolerated and highly effective therapies in this patient population represent an unmet need. Preclinical studies have shown that B-cell maturation antigen is nearly exclusively expressed on normal and malignant plasma cells, thereby identifying it as a highly selective target for immunotherapeutic approaches. Belantamab mafodotin (GSK2857916, belamaf) is a first-in-class antibody-drug conjugate directed at B-cell maturation antigen and has shown promising activity in clinical trials. In this review, we provide an overview of belantamab mafodotin as a compound and present the available clinical efficacy and safety data in the treatment of relapsed/refractory multiple myeloma.
Keyphrases
- multiple myeloma
- clinical trial
- acute lymphoblastic leukemia
- acute myeloid leukemia
- end stage renal disease
- induced apoptosis
- newly diagnosed
- prognostic factors
- chronic kidney disease
- randomized controlled trial
- electronic health record
- machine learning
- combination therapy
- cell proliferation
- pi k akt
- endoplasmic reticulum stress
- deep learning
- study protocol
- replacement therapy
- phase iii
- placebo controlled