Azithromycin and ciprofloxacin inhibit interleukin-8 secretion without disrupting human sinonasal epithelial integrity in vitro.
Dong-Jin LimHarrison M ThompsonChristopher R WalzSamrath AyinalaDaniel SkinnerShaoyan ZhangJessica W GraysonDo-Yeon ChoBradford A WoodworthPublished in: International forum of allergy & rhinology (2020)
Azithromycin decreased P. aeruginosa LPS IL-8 production in HSNECs at drug concentrations attainable with sustained release of azithromycin from the CASS. In addition to antibacterial activity, anti-inflammatory properties of the CASS should provide further benefit for patients with recalcitrant CRS.