Repeated ethanol exposure and withdrawal alters angiotensin-converting enzyme 2 expression in discrete brain regions: Implications for SARS-CoV-2 neuroinvasion.

Nagalakshmi BalasubramanianThomas D JamesGovindhasamy Pushpavathi SelvakumarJessica ReinhardtCatherine A Marcinkiewcz

Published in: Alcoholism, clinical and experimental research (2023)

Our results suggest that alcohol triggers a compensatory upregulation of ACE2 in the brain due to disturbed RAS and may increase the risk or severity of SARS-CoV-2 infection.

Keyphrases

angiotensin converting enzyme
angiotensin ii
sars cov
poor prognosis
resting state
white matter
respiratory syndrome coronavirus
functional connectivity
cerebral ischemia
cell proliferation
signaling pathway
multiple sclerosis
long non coding rna
subarachnoid hemorrhage
blood brain barrier
alcohol consumption