Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos.

Rajiv C McCoyMichael C SummersAbeo McCollinChristian Simon OttoliniKamal AhujaAlan H Handyside

Published in: Genome medicine (2023)

We conclude that the combination of meiotic and mitotic aneuploidies drives arrest of human embryos in vitro, as development increasingly relies on embryonic gene expression at the blastocyst stage.

Keyphrases

cell cycle
gene expression
endothelial cells
pluripotent stem cells
dna methylation