Decreased expression of programmed death-1 on CD8+ effector memory T lymphocytes correlates with the pathogenesis of type 1 diabetes.

Yimei ShanYinghong KongYan ZhouJingjing GuoQiyun ShiSicheng LiHeming GuoYiting HuangSisi DingCuiping LiuLei CaoYun HuangChen FangJi Hu

Published in: Acta diabetologica (2021)

It is the first report of the expression of PD-1 on CD8+ Tem cells in T1D in the present study. Our observations suggest that the PD-1/PD-L1 signal pathway on CD8+ Tem cells of T1D subjects might identify a new pathway for delaying the occurrence and development by inhibiting autoimmunity.

Keyphrases

induced apoptosis
type diabetes
poor prognosis
cell cycle arrest
signaling pathway
risk assessment
nk cells
cardiovascular disease
oxidative stress
regulatory t cells
binding protein
working memory
insulin resistance
cell proliferation
type iii