The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.

Irina V TcymbarevichJyrki J ElorantaJean-Benoît RosselNicole ObialoMarianne SpalingerJesus Cosin-RogerSilvia LangGerd A Kullak-UblickCarsten A WagnerMichael ScharlKlaus SeuwenPedro A RuizGerhard RoglerCheryl de VallièreBenjamin Misselwitznull null

Published in: BMC gastroenterology (2019)

The T allele of rs8005161 might confer a more severe disease course in IBD patients. Human monocytes from IBD patients showed impaired pH associated RhoA activation upon an acidic pH shift.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
endothelial cells
patient reported outcomes
early onset
fatty acid