Hepatitis B Virus-Mediated m6A Demethylation Increases Hepatocellular Carcinoma Stemness and Immune Escape.

Yuting Meng Zheyue Shu Xueyao Wang Liang Hong Baohua Wang Jingjing Jiang Kangxin He Qingyi Cao Fan Shi Hai Wang Lan Gong Hongyan Diao

Published in: Molecular cancer research : MCR (2024)

HBV promotes HCC stemness maintenance through elevate m6A modification of SNAI2 in an ALKBH5-YTHDF2-dependent manner and increases the expression of the ligand of immune checkpoint CD155.

Keyphrases

hepatitis b virus
stem cells
epithelial mesenchymal transition
liver failure
poor prognosis
cancer stem cells
binding protein
nk cells