Effects of Bumetanide on Neurocognitive Functioning in Children with Autism Spectrum Disorder: Secondary Analysis of a Randomized Placebo-Controlled Trial.
Dorinde M van AndelJan J SprengersMarsh KönigsMaretha V de JongeHilgo BruiningPublished in: Journal of autism and developmental disorders (2023)
We present the secondary-analysis of neurocognitive tests in the 'Bumetanide in Autism Medication and Biomarker' (BAMBI;EUDRA-CT-2014-001560-35) study, a randomized double-blind placebo-controlled (1:1) trial testing 3-months bumetanide treatment (≤ 1 mg twice-daily) in unmedicated children 7-15 years with ASD. Children with IQ ≥ 70 were analyzed for baseline deficits and treatment-effects on the intention-to-treat-population with generalized-linear-models, principal component analysis and network analysis. Ninety-two children were allocated to treatment and 83 eligible for analyses. Heterogeneous neurocognitive impairments were found that were unaffected by bumetanide treatment. Network analysis showed higher modularity after treatment (mean difference:-0.165, 95%CI:-0.317 to - 0.013,p = .034) and changes in the relative importance of response inhibition in the neurocognitive network (mean difference:-0.037, 95%CI:-0.073 to - 0.001,p = .042). This study offers perspectives to include neurocognitive tests in ASD trials.
Keyphrases
- network analysis
- double blind
- autism spectrum disorder
- bipolar disorder
- young adults
- healthcare
- computed tomography
- randomized controlled trial
- attention deficit hyperactivity disorder
- emergency department
- intellectual disability
- magnetic resonance imaging
- magnetic resonance
- traumatic brain injury
- physical activity
- study protocol
- positron emission tomography
- smoking cessation
- placebo controlled
- image quality
- working memory