Double-blind, randomized controlled trial of therapeutic plasma exchanges vs sham exchanges in moderate-to-severe relapses of multiple sclerosis.

Bruno BrochetMathilde DeloireChristine GermainJean-Christophe OualletLinda WittkopCécile DulauPaul PerezFlorian ThevenotJérome De SèzeHélène ZéphirPatrick VermerschSophie PittionMarc DebouverieDavid-Axel LaplaudPierre ClavelouAurélie Ruet

Published in: Journal of clinical apheresis (2020)

A significant difference between TPE and Sham-TPE at the primary endpoint was only observed in patients with ON. Neurological function improved significantly more often in the TPE group than in the sham-TPE group.

Keyphrases

double blind
multiple sclerosis
randomized controlled trial
placebo controlled
study protocol
clinical trial
phase iii
high intensity
phase ii
early onset
systematic review
white matter
open label
blood brain barrier
subarachnoid hemorrhage
drug induced