PRAME Staining in Sinonasal Mucosal Melanoma: A Single-Center Experience.

Willem Frederik Julius ScheurleerW Weibel BrauniusBernard M TijinkKarijn P M SuijkerbuijkMiranda P DierselhuisRuud W J MeijersWilleke A M BlokxRemco de BreeGerben E BreimerJohannes A Rijken

Published in: Head and neck pathology (2022)

We show that expression of PRAME is common in sinonasal MM, making PRAME a useful ancillary diagnostic tool and a potential therapeutic target in sinonasal MM. The demonstrated occurrence of extensive presence of PRAME-positive melanocytes in the surrounding mucosa of sinonasal MM might explain the multifocal nature of melanoma in the (sinonasal) mucosa, and would be an extra argument for a PRAME targeting treatment in preventing local disease recurrence.

Keyphrases

chronic rhinosinusitis
poor prognosis
risk assessment
binding protein
cancer therapy
climate change