Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte.
Jia LiJoakim SundnesYufeng HouMartin LaasmaaMarianne RuudAndreas UngerTerje R KolstadMichael FriskPer Andreas NorsengLimin YangIngunn E SetterbergEstela S AlvesMichaeljohn KalakoutisOle M SejerstedJohanna T LannerWolfgang A LinkeIda Gjervold LundePieter P de TombeWilliam Edward LouchPublished in: Circulation research (2023)
Graded sarcomere recruitment directs cardiomyocyte work performance, and harmonization of sarcomere strain increases contractility during cell stretch. By setting sarcomere dimensions, titin controls sarcomere recruitment, and its lowered expression in haploinsufficiency mutations impairs cardiomyocyte contractility.