Potential Prognostic Role of 18F-FDG PET/CT in Invasive Epithelial Ovarian Cancer Relapse. A Preliminary Study.
Anna Myriam PerroneGiulia DondiGiacomo Maria LimaPaolo CastellucciMarco TeseiSara ColuccelliGiuseppe GasparreAnna Maria PorcelliCristina NanniStefano FantiPierandrea De IacoPublished in: Cancers (2019)
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, with relapse occurring in about 70% of advanced cases with poor prognosis. Fluorine-18-2-fluoro-2-deoxy-d-glucose PET/CT (18F-FDGPET/CT) is the most specific radiological imaging used to assess recurrence. Some intensity-based and volume-based PET parameters, maximum standardized uptake values (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), are indicated to have a correlation with treatment response. The aim of our study is to correlate these parameters with post relapse survival (PRS) and overall survival (OS) in Epithelial Ovarian Cancer (EOC) relapse. The study included 50 patients affected by EOC relapse who underwent 18F-FDGPET/CT before surgery. All imaging was reviewed and SUVmax, MTV and TLG were calculated and correlated to PRS and OS. PRS and OS were obtained from the first relapse and from the first diagnosis to the last follow up or death, respectively. SUVmax, MTV and TLG were tested in a univariate logistic regression analysis, only SUVmax demonstrated to be significantly associated to PRS and OS (p = 0.005 and p = 0.024 respectively). Multivariate analysis confirmed the results. We found a cut-off of SUVmax of 13 that defined worse or better survival (p = 0.003). In the first relapse of EOC, SUVmax is correlated to PRS and OS, and when SUVmax is greater than 13, it is an unfavorable prognostic factor.
Keyphrases
- free survival
- positron emission tomography
- pet ct
- poor prognosis
- prognostic factors
- computed tomography
- high resolution
- long non coding rna
- minimally invasive
- metabolic syndrome
- magnetic resonance imaging
- newly diagnosed
- contrast enhanced
- risk assessment
- dual energy
- magnetic resonance
- photodynamic therapy
- human health
- blood pressure
- glycemic control