Randomised clinical trial: oesophageal radiofrequency energy delivery versus sham for PPI-refractory heartburn.

Frank ZerbibSylvie Sacher-HuvelinEmmanuel CoronBenoit CoffinChloé MelchiorThierry PonchonFranck CholetEdouard ChabrunFabienne VavasseurCaroline GorbatchefAlberto ZalarFrançois MionMichel RobaszkiewiczMarc Le RhunMaxime LeroyJean Paul GalmicheStanislas Bruley des Varannes

Published in: Alimentary pharmacology & therapeutics (2020)

This sham-controlled, randomised study did not demonstrate any efficacy of oesophageal radiofrequency for the treatment of PPI-refractory heartburn regarding symptom relief or consumption of PPIs. ClinicalTrials.gov NCT01682265.

Keyphrases

double blind
clinical trial
open label
placebo controlled
study protocol
phase ii
protein protein
phase iii
catheter ablation
ultrasound guided
randomized controlled trial
small molecule
combination therapy
smoking cessation