Expression of mycobacterium tuberculosis induced SOCS3 and STAT3 and the implications on innate immunity in TB patients vs healthy contacts in high TB/HIV endemic setting: A cross-sectional analytical study.
Patrick Saili LunguKabaso MushotaEvarist NjelesaniThomas SukwaShabir LakhiPeter MwabaPublished in: PloS one (2022)
Both SOCS3 and STAT3 are genes of importance in mounting protective innate immunity against TB. We propose that SOCS3 stimulation and inhibition of STAT3 as possible approaches in gene therapy and vaccine development for TB.
Keyphrases
- mycobacterium tuberculosis
- gene therapy
- cell proliferation
- pulmonary tuberculosis
- end stage renal disease
- ejection fraction
- newly diagnosed
- poor prognosis
- chronic kidney disease
- human immunodeficiency virus
- hiv positive
- hiv infected
- prognostic factors
- hepatitis c virus
- hiv testing
- genome wide
- high glucose
- men who have sex with men
- transcription factor
- oxidative stress
- south africa
- binding protein
- liquid chromatography