Chronic consumption of fructose in combination with trans fatty acids but not with saturated fatty acids induces nonalcoholic steatohepatitis with fibrosis in rats.

Sugeedha JeyapalUday Kumar PutchaVenkata Surekha MullapudiSudip GhoshAnil SakamuriSuryam Reddy KonaSai Santosh VadakattuChandana MadakasiraAhamed Ibrahim

Published in: European journal of nutrition (2017)

Fructose in combination with TFA caused NASH with fibrosis by inducing oxidative stress and inflammation, whereas, fructose in combination with SFA caused simple steatosis, suggesting that the type of fatty acid is more important for the progression of NAFLD.

Keyphrases

fatty acid
oxidative stress
dna damage
insulin resistance
high fat diet
type diabetes
skeletal muscle
adipose tissue
endoplasmic reticulum stress
signaling pathway
heat shock