Intratumoral Delivery of Chimeric Antigen Receptor-T Cells Targeting CD133 Effectively Treats Brain Metastases.

Agata Monika Kieliszek Daniel Mobilio Deepak Upreti Darin Bloemberg Laura Escudero Jacek M Kwiecien Zahra Alizada Kui Zhai Patrick Ang Shawn Christopher Chafe Parvez Vora Chitra Venugopal Sheila K Singh

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

In summary, these data suggest that CD133 plays a critical role in fueling the growth of BM, and immunotherapeutic targeting of this cell population is a feasible strategy to control the outgrowth of BM tumors that are otherwise limited to palliative care.

Keyphrases

brain metastases
palliative care
small cell lung cancer
cancer therapy
single cell
nk cells
electronic health record
advanced cancer
cell therapy
big data
machine learning
mesenchymal stem cells
bone marrow
deep learning