Maternal oxidized soybean oil exposure in rats during lactation damages offspring kidneys via Nrf2/HO-1 and NF-κB signaling pathway.
Feng GaoZhiqiang GuoYanan GaoChuanqi WangHuiting WangXinxin YaoBao-Ming ShiPublished in: Journal of the science of food and agriculture (2021)
These findings indicated that the kidneys of two generations of rats were compromised by oxidative damage when fed OSO during lactation. This study provides evidence for increasing the genes expression of the Nrf2/heme oxygenase 1 pathway to alleviate the kidney damage caused by OSO in the mother and offspring. © 2021 Society of Chemical Industry.
Keyphrases
- signaling pathway
- oxidative stress
- pi k akt
- human milk
- high fat diet
- dairy cows
- poor prognosis
- induced apoptosis
- genome wide
- epithelial mesenchymal transition
- lps induced
- adipose tissue
- gene expression
- type diabetes
- body mass index
- skeletal muscle
- metabolic syndrome
- bioinformatics analysis
- inflammatory response
- dna methylation