Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children.
Jonatan LefflerJames F ReadAnya C JonesDanny MokElysia M HollamsIngrid A LaingPeter N Le SouefPeter D SlyMerci M H KuselNicholas H de KlerkAnthony BoscoPatrick G HoltDeborah H StricklandPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2019)
Our data suggest that the expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children. Given the significant immune modulatory effects observed as a consequence of FcεRI expression, this altered expression pattern is likely to contribute to asthma pathology in children.