New Insights into Pathophysiology and New Risk Factors for ACS.
Matteo NardinMonica VerdoiaNicola LaeraDavide CaoGiuseppe De LucaPublished in: Journal of clinical medicine (2023)
Cardiovascular disease still represents the main cause of mortality worldwide. Despite huge improvements, atherosclerosis persists as the principal pathological condition, both in stable and acute presentation. Specifically, acute coronary syndromes have received substantial research and clinical attention in recent years, contributing to improve overall patients' outcome. The identification of different evolution patterns of the atherosclerotic plaque and coronary artery disease has suggested the potential need of different treatment approaches, according to the mechanisms and molecular elements involved. In addition to traditional risk factors, the finer portrayal of other metabolic and lipid-related mediators has led to higher and deep knowledge of atherosclerosis, providing potential new targets for clinical management of the patients. Finally, the impressive advances in genetics and non-coding RNAs have opened a wide field of research both on pathophysiology and the therapeutic side that are extensively under investigation.
Keyphrases
- cardiovascular disease
- end stage renal disease
- risk factors
- coronary artery disease
- acute coronary syndrome
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- type diabetes
- prognostic factors
- peritoneal dialysis
- risk assessment
- left ventricular
- heart failure
- patient reported outcomes
- cardiovascular events
- fatty acid
- human health
- coronary artery bypass grafting
- drug induced