Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis.

Emma L AndersonRebecca C RichmondSamuel E JonesGibran HemaniKaitlin H WadeHassan S DashtiJacqueline M LaneHeming WangRicha SaxenaBen BrumptonRoxanna Korologou-LindenJonas B NielsenBjørn Olav ÅsvoldGonçalo AbecasisElizabeth CoulthardSimon D KyleRobin N BeaumontJessica TyrrellTimothy M FraylingMarcus R MunafòAndrew R WoodYoav Ben-ShlomoLaura D HoweDeborah A LawlorMichael N WeedonGeorge Davey Smith

Published in: International journal of epidemiology (2021)

Overall, we found very limited evidence to support a causal effect of sleep traits on AD risk. Our findings provide tentative evidence that daytime napping may reduce AD risk. Given that this is the first MR study of multiple self-report and objective sleep traits on AD risk, findings should be replicated using independent samples when such data become available.

Keyphrases

sleep quality
physical activity
magnetic resonance
cognitive decline
gene expression
depressive symptoms
big data