Elevated nuclear expression of ZHX1 correlates with poor prognosis in hepatocellular carcinoma (HCC): Comparison of nuclear and cytoplasmic distribution of the ZHX family in HCC cells.

Yu-Hong MaShinya MaekawaShinichi TakanoTatsuya YamaguchiTakeshi IshidaShinya TakaokaMasaru MuraokaYasuyuki KomiyamaHitomi TakadaYuichiro SuzukiMitsuaki SatoJianglin FanNobuyuki Enomoto

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2024)

These results suggest that the expression and localization of different ZHXs may be related to HCC progression, potentially inferring genetic backgrounds such as TERT promoter mutation. Further studies on the relationship between HCC and ZHXs will enhance our understanding and control of HCC.

Keyphrases

poor prognosis
long non coding rna
induced apoptosis
transcription factor
binding protein
signaling pathway
oxidative stress
cell proliferation
cell death
endoplasmic reticulum stress
drug induced