Beneficial effects of MGL-3196 and BAM15 combination in a mouse model of fatty liver disease.

Mingyan ZhouCatherine LiFrances L ByrneCalum S VancuylenburgEllen M OlzomerAdam HargreavesLindsay E WuNicholas A ShackelWebster L SantosKyle Lee Hoehn

Published in: Acta physiologica (Oxford, England) (2024)

MGL + BAM15 treatment had overall better efficacy to improve metabolic outcomes in mice fed GAN diet than either monotherapy alone. These data warrant further investigation into combination therapies of THR-β agonists and mitochondrial uncouplers for the potential treatment of disorders related to fatty liver, obesity, and insulin resistance.

Keyphrases

insulin resistance
high fat diet induced
mouse model
metabolic syndrome
type diabetes
weight loss
combination therapy
adipose tissue
oxidative stress
physical activity
high fat diet
machine learning
risk assessment
fatty acid
climate change
human health
glycemic control
artificial intelligence