Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer.
Shuchi GulatiJanki M DesaiSarah M PalackdharryJohn C MorrisZheng ZhuRoman JandarovMuhammed Kashif RiazVinita TakiarMichelle Lynn MierzwaJorge Silvio GutkindAlfredo MolinoloPankaj B DesaiNooshin Hashemi SadraeiTrisha Michel Wise-DraperPublished in: Cancer (2019)
To the authors' knowledge, the current study is the first phase 1 trial combining metformin with chemoradiotherapy. Rates of overall survival and progression-free survival were encouraging in this limited patient population, and warrant further investigation in a phase 2 trial.