Jorge Silvio Gutkind (J S Gutkind, J Silvio Gutkind)

Scopus Author ID ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 52

Top Venues

Science signaling

Nature communications

Nature cancer

Cancer research communications

University of California San Diego

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of California San Diego Sep 01 2015

United States

Distinguished Professor, and Associate Director of Basic Science, Moores Cancer Center :: Pharmacology

National Institute of Dental and Craniofacial Research - Aug 31 2015

United States

Branch Chief :: Oral and Pharyngeal Cancer Branch

Publications

Michael Trogdon, Kodye Abbott, Nadia Arang, Kathryn Lande, Navneet Kaur, Melinda Tong, Mathieu Bakhoum, Jorge Silvio Gutkind, Edward Cooper Stites
Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation. NPJ systems biology and applications 10 (1) (2024)
Yusuke Goto, Keiichi Koshizuka, Toshinori Ando, Hiroki Izumi, Xingyu Wu, Kuniaki Sato, Tomohiko Ishikawa, Kyle Ford, Xiaodong Feng, Zhiyong Wang, Nadia Arang, Michael M Allevato, Ayush Kishore, Prashant Mali, Jorge Silvio Gutkind
A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC. Cancer research communications 4 (7) (2024)
Matthew J Hangauer, Jorge Silvio Gutkind, Fleur M Ferguson
Pan-RAF:MEK Molecular Glues Take Center Stage. Cancer discovery 14 (7) (2024)
Yusuke Goto, Keiichi Koshizuka, Toshinori Ando, Hiroki Izumi, Xingyu Wu, Kuniaki Sato, Tomohiko Ishikawa, Kyle Ford, Xiaodong Feng, Zhiyong Wang, Nadia Arang, Michael M Allevato, Ayush Kishore, Prashant Mali, Jorge Silvio Gutkind
A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC. Cancer research communications 4 (7) (2024)
Franziska Haderk, Yu-Ting Chou, Lauren Cech, Celia Fernández-Méndez, Johnny Yu, Victor Olivas, Ismail M Meraz, Dora Barbosa Rabago, D Lucas Kerr, Carlos Gomez, David V Allegakoen, Juan Guan, Khyati N Shah, Kari A Herrington, Oghenekevwe M Gbenedio, Shigeki Nanjo, Mourad Majidi, Whitney Tamaki, Yashar K Pourmoghadam, Julia K Rotow, Caroline E McCoach, Jonathan W Riess, Jorge Silvio Gutkind, Tracy T Tang, Leonard Post, Bo Huang, Pilar Santisteban, Hani Goodarzi, Sourav Bandyopadhyay, Calvin J Kuo, Jeroen P Roose, Wei Wu, Collin M Blakely, Jack A Roth, Trever G Bivona
Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Nature communications 15 (1) (2024)
Franziska Haderk, Yu-Ting Chou, Lauren Cech, Celia Fernández-Méndez, Johnny Yu, Victor Olivas, Ismail M Meraz, Dora Barbosa Rabago, D Lucas Kerr, Carlos Gomez, David V Allegakoen, Juan Guan, Khyati N Shah, Kari A Herrington, Oghenekevwe M Gbenedio, Shigeki Nanjo, Mourad Majidi, Whitney Tamaki, Yashar K Pourmoghadam, Julia K Rotow, Caroline E McCoach, Jonathan W Riess, Jorge Silvio Gutkind, Tracy T Tang, Leonard Post, Bo Huang, Pilar Santisteban, Hani Goodarzi, Sourav Bandyopadhyay, Calvin J Kuo, Jeroen P Roose, Wei Wu, Collin M Blakely, Jack A Roth, Trever G Bivona
Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Nature communications 15 (1) (2024)
Matthew J Hangauer, Jorge Silvio Gutkind, Fleur M Ferguson
Pan-RAF:MEK Molecular Glues Take Center Stage. Cancer discovery 14 (7) (2024)
Yusuke Goto, Keiichi Koshizuka, Toshinori Ando, Hiroki Izumi, Xingyu Wu, Kuniaki Sato, Tomohiko Ishikawa, Kyle Ford, Xiaodong Feng, Zhiyong Wang, Nadia Arang, Michael M Allevato, Ayush Kishore, Prashant Mali, Jorge Silvio Gutkind
A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC. Cancer research communications 4 (7) (2024)
Michael Trogdon, Kodye Abbott, Nadia Arang, Kathryn Lande, Navneet Kaur, Melinda Tong, Mathieu Bakhoum, Jorge Silvio Gutkind, Edward Cooper Stites
Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation. NPJ systems biology and applications 10 (1) (2024)
Franziska Haderk, Yu-Ting Chou, Lauren Cech, Celia Fernández-Méndez, Johnny Yu, Victor Olivas, Ismail M Meraz, Dora Barbosa Rabago, D Lucas Kerr, Carlos Gomez, David V Allegakoen, Juan Guan, Khyati N Shah, Kari A Herrington, Oghenekevwe M Gbenedio, Shigeki Nanjo, Mourad Majidi, Whitney Tamaki, Yashar K Pourmoghadam, Julia K Rotow, Caroline E McCoach, Jonathan W Riess, Jorge Silvio Gutkind, Tracy T Tang, Leonard Post, Bo Huang, Pilar Santisteban, Hani Goodarzi, Sourav Bandyopadhyay, Calvin J Kuo, Jeroen P Roose, Wei Wu, Collin M Blakely, Jack A Roth, Trever G Bivona
Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Nature communications 15 (1) (2024)
Michael Trogdon, Kodye Abbott, Nadia Arang, Kathryn Lande, Navneet Kaur, Melinda Tong, Mathieu Bakhoum, Jorge Silvio Gutkind, Edward Cooper Stites
Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation. NPJ systems biology and applications 10 (1) (2024)
Franziska Haderk, Yu-Ting Chou, Lauren Cech, Celia Fernández-Méndez, Johnny Yu, Victor Olivas, Ismail M Meraz, Dora Barbosa Rabago, D Lucas Kerr, Carlos Gomez, David V Allegakoen, Juan Guan, Khyati N Shah, Kari A Herrington, Oghenekevwe M Gbenedio, Shigeki Nanjo, Mourad Majidi, Whitney Tamaki, Yashar K Pourmoghadam, Julia K Rotow, Caroline E McCoach, Jonathan W Riess, Jorge Silvio Gutkind, Tracy T Tang, Leonard Post, Bo Huang, Pilar Santisteban, Hani Goodarzi, Sourav Bandyopadhyay, Calvin J Kuo, Jeroen P Roose, Wei Wu, Collin M Blakely, Jack A Roth, Trever G Bivona
Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Nature communications 15 (1) (2024)
Franziska Haderk, Yu-Ting Chou, Lauren Cech, Celia Fernández-Méndez, Johnny Yu, Victor Olivas, Ismail M Meraz, Dora Barbosa Rabago, D Lucas Kerr, Carlos Gomez, David V Allegakoen, Juan Guan, Khyati N Shah, Kari A Herrington, Oghenekevwe M Gbenedio, Shigeki Nanjo, Mourad Majidi, Whitney Tamaki, Yashar K Pourmoghadam, Julia K Rotow, Caroline E McCoach, Jonathan W Riess, Jorge Silvio Gutkind, Tracy T Tang, Leonard Post, Bo Huang, Pilar Santisteban, Hani Goodarzi, Sourav Bandyopadhyay, Calvin J Kuo, Jeroen P Roose, Wei Wu, Collin M Blakely, Jack A Roth, Trever G Bivona
Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer. Nature communications 15 (1) (2024)
Yusuke Goto, Keiichi Koshizuka, Toshinori Ando, Hiroki Izumi, Xingyu Wu, Kuniaki Sato, Tomohiko Ishikawa, Kyle Ford, Xiaodong Feng, Zhiyong Wang, Nadia Arang, Michael M Allevato, Ayush Kishore, Prashant Mali, Jorge Silvio Gutkind
A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC. Cancer research communications 4 (7) (2024)
Yusuke Goto, Keiichi Koshizuka, Toshinori Ando, Hiroki Izumi, Xingyu Wu, Kuniaki Sato, Tomohiko Ishikawa, Kyle Ford, Xiaodong Feng, Zhiyong Wang, Nadia Arang, Michael M Allevato, Ayush Kishore, Prashant Mali, Jorge Silvio Gutkind
A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCC. Cancer research communications (2024)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer 4 (2) (2023)
Victoria H Wu, Bryan S Yung, Farhoud Faraji, Robert Saddawi-Konefka, Zhiyong Wang, Alexander T Wenzel, Miranda J Song, Meghana S Pagadala, Lauren M Clubb, Joshua Chiou, Sanju Sinha, Marin Matic, Francesco Raimondi, Thomas S Hoang, Rebecca Berdeaux, Dario A A Vignali, Ramiro Iglesias-Bartolome, Hannah Carter, Eytan Ruppin, Jill P Mesirov, Jorge Silvio Gutkind
The GPCR-Gα s -PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure. Nature immunology (2023)
Farhoud Faraji, Sydney I Ramirez, Lauren M Clubb, Kuniaki Sato, Paola Y Anguiano Quiroz, William M G Galloway, Zbigniew Mikulski, Thomas S Hoang, Kate Medetgul-Ernar, Pauline Marangoni, Kyle B Jones, Adam Officer, Napoleone Ferrara, Kenneth Kim, Kanako Sakaguchi, Joseph A Califano, Quinton Smith, Ophir D Klein, Pablo Tamayo, Jorge Silvio Gutkind
Direct reprogramming of oral epithelial progenitor cells to cancer stem cells at single cell resolution in vivo . bioRxiv : the preprint server for biology (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Jorge Silvio Gutkind, Farhoud Faraji, Sydney Ramirez, Lauren Clubb, Kuniaki Sato, Paola Anguiano Quiroz, William Galloway, Zbigniew Mikulski, Thomas Hoang, Kate Medetgul-Ernar, Pauline Marangoni, Kyle Jones, Adam Officer, Alfredo Molinolo, Kenneth Kim, Kanako Sakaguchi, Joseph Califano, Quinton Smith, Ophir Klein, Pablo Tamayo
YAP-Driven Malignant Reprogramming of Epithelial Stem Cells at Single Cell Resolution. Research square (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer 4 (2) (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer 4 (2) (2023)
Sankar Jagadeeshan, Manu Prasad, Mai Badarni, Talal Ben Lulu, Vijayasteltar Belsamma Liju, Sooraj Mathukkada, Claire J Saunders, Avital Beeri Shnerb, Jonathan Zorea, Ksenia M Yegodayev, Monica Wainer, Liza Vtorov, Irit Allon, Ofir Cohen, Gro Gausdal, Dinorah Friedmann-Morvinski, Sok Ching Cheong, Alan L Ho, Ari J Rosenberg, Linda Kessler, Francis Burrows, Dexin Kong, Jennifer R Grandis, Jorge Silvio Gutkind, Moshe Elkabets
Mutated HRAS activates YAP1-AXL signaling to drive metastasis of head and neck cancer. Cancer research (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Alison E Smith, Stacia Chan, Zhiyong Wang, Asako McCloskey, Quinn Reilly, Jayden Z Wang, Hetika Vora Patel, Keiichi Koshizuka, Harris S Soifer, Linda Kessler, Ashley Dayoub, Victoria M Villaflor, Douglas R Adkins, Justine Yang Bruce, Alan L Ho, Cesar A Perez, Glenn J Hanna, Amaya Gasco Hernandez, Andrew Saunders, Stephen Dale, Jorge Silvio Gutkind, Francis Burrows, Shivani Malik
Tipifarnib potentiates the antitumor effects of PI3Kα inhibition in PIK3CA- and HRAS-dysregulated HNSCC via convergent inhibition of mTOR activity. Cancer research (2023)
Ana Ruiz-Saenz, Chloe E Atreya, Changjun Wang, Qiang Sun, Courtney A Dreyer, Diede Brunen, Anirudh Prahallad, Denise P Muñoz, Dana J Ramms, Valeria Burghi, Danislav S Spassov, Eleanor Fewings, Y Christina Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M Wolf, Byron Hann, Scott R VandenBerg, Kevan M Shokat, Mark M Moasser, René Bernards, Jorge Silvio Gutkind, Laura van 't Veer, Jean-Philippe Coppé
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF V600E colorectal tumors. Nature cancer 4 (2) (2023)
Xin Zhao, Ezra E W Cohen, William N William, Joy J Bianchi, Jim P Abraham, Daniel Magee, David B Spetzler, Jorge Silvio Gutkind, Ludmil B Alexandrov, Webster K Cavenee, Scott M Lippman, Teresa Davoli
Somatic 9p24.1 alterations in HPV - head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity. Proceedings of the National Academy of Sciences of the United States of America 119 (47) (2022)
Robert Saddawi-Konefka, Aoife O'Farrell, Farhoud Faraji, Lauren Clubb, Michael M Allevato, Shawn M Jensen, Bryan S Yung, Zhiyong Wang, Victoria H Wu, Nana-Ama A S Anang, Riyam Al Msari, Shiruyeh Schokrpur, Ida Franiak Pietryga, Alfredo A Molinolo, Jill P Mesirov, Aaron B Simon, Bernard A Fox, Jack D Bui, Andrew Sharabi, Ezra E W Cohen, Joseph A Califano, Jorge Silvio Gutkind
Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC. Nature communications 13 (1) (2022)
Kris C Wood, Jorge Silvio Gutkind
Challenges and Emerging Opportunities for Targeting mTOR in Cancer. Cancer research 82 (21) (2022)
Cherie Ann O Nathan, David Neil Hayes, Theodore Karrison, Olivier Harismendy, José M Flores, Tara Moore-Medlin, Everett E Vokes, Jorge Silvio Gutkind, Prakash Neupane, Glenn Mills, Zoukaa Sargi, Tanguy Seiwert, Juneko E Grilley Olson, Terry A Day, Maura L Gillison, James L Wade, Lawrence E Feldman, Gautam Jha, Mark Kozloff, Miriam O'Leary, Francis P Worden, Ezra E W Cohen
A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (23) (2022)
Zhiyong Wang, Yusuke Goto, Michael M Allevato, Victoria H Wu, Robert Saddawi-Konefka, Mara Gilardi, Diego Alvarado, Bryan S Yung, Aoife O'Farrell, Alfredo A Molinolo, Umamaheswar Duvvuri, Jennifer R Grandis, Joseph A Califano, Ezra E W Cohen, Jorge Silvio Gutkind
Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer. Nature communications 12 (1) (2021)
Nadia Arang, Jorge Silvio Gutkind
G Protein-Coupled receptors and heterotrimeric G proteins as cancer drivers. FEBS letters 594 (24) (2021)
Danielle L Swaney, Dana J Ramms, Zhiyong Wang, Jisoo Park, Yusuke Goto, Margaret Soucheray, Neil Bhola, Kyumin Kim, Fan Zheng, Yan Zeng, Michael J McGregor, Kari A Herrington, Rachel A O'Keefe, Nan Jin, Nathan K VanLandingham, Helene Foussard, John Von Dollen, Mehdi Bouhaddou, David Jimenez-Morales, Kirsten Obernier, Jason F Kreisberg, Minkyu Kim, Daniel E Johnson, Natalia Jura, Jennifer R Grandis, Jorge Silvio Gutkind, Trey Ideker, Nevan J Krogan
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. Science (New York, N.Y.) 374 (6563) (2021)
Fan Zheng, Marcus R Kelly, Dana J Ramms, Marissa L Heintschel, Kai Tao, Beril Tutuncuoglu, John J Lee, Keiichiro Ono, Helene Foussard, Michael Chen, Kari A Herrington, Erica Silva, Sophie N Liu, Jing Chen, Christopher P Churas, Nicholas Wilson, Anton Kratz, Rudolf T Pillich, Devin N Patel, Jisoo Park, Brent M Kuenzi, Michael K Yu, Katherine Licon, Dexter Pratt, Jason F Kreisberg, Minkyu Kim, Danielle L Swaney, Xiaolin Nan, Stephanie I Fraley, Jorge Silvio Gutkind, Nevan J Krogan, Trey Ideker
Interpretation of cancer mutations using a multiscale map of protein systems. Science (New York, N.Y.) 374 (6563) (2021)
Toshinori Ando, Nadia Arang, Zhiyong Wang, Daniela Elena Costea, Xiaodong Feng, Yusuke Goto, Hiroki Izumi, Mara Gilardi, Kazuyo Ando, Jorge Silvio Gutkind
EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. Communications biology 4 (1) (2021)
Yusuke Goto, Toshinori Ando, Hiroki Izumi, Xiaodong Feng, Nadia Arang, Mara Gilardi, Zhiyong Wang, Kazuyo Ando, Jorge Silvio Gutkind
Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis. Oncogene 39 (20) (2020)
Amber N Stratman, Olivia M Farrelly, Constantinos M Mikelis, Mayumi F Miller, Zhiyong Wang, Van N Pham, Andrew E Davis, Margaret C Burns, Sofia A Pezoa, Daniel Castranova, Joseph J Yano, Tina M Kilts, George E Davis, Jorge Silvio Gutkind, Brant M Weinstein
Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling. Nature communications 11 (1) (2020)
Shuling Ren, Daria A Gaykalova, Theresa Guo, Alexander V Favorov, Elana J Fertig, Pablo Tamayo, Juan Luis Callejas-Valera, Mike Allevato, Mara Gilardi, Jessica Santos, Takahito Fukusumi, Akihiro Sakai, Mizuo Ando, Sayed Sadat, Chao Liu, Guorong Xu, Kathleen M Fisch, Zhiyong Wang, Alfredo A Molinolo, Jorge Silvio Gutkind, Trey Ideker, Wayne M Koch, Joseph A Califano
HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers. Oncogene 39 (40) (2020)
Zhiyong Wang, Victoria H Wu, Michael M Allevato, Mara Gilardi, Yudou He, Juan Luis Callejas-Valera, Lynn Vitale-Cross, Daniel Martin, Panomwat Amornphimoltham, James Mcdermott, Bryan S Yung, Yusuke Goto, Alfredo A Molinolo, Andrew B Sharabi, Ezra E W Cohen, Qianming Chen, J Guy Lyons, Ludmil B Alexandrov, Jorge Silvio Gutkind
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4. Nature communications 10 (1) (2019)
Shuchi Gulati, Janki M Desai, Sarah M Palackdharry, John C Morris, Zheng Zhu, Roman Jandarov, Muhammed Kashif Riaz, Vinita Takiar, Michelle Lynn Mierzwa, Jorge Silvio Gutkind, Alfredo Molinolo, Pankaj B Desai, Nooshin Hashemi Sadraei, Trisha Michel Wise-Draper
Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer. Cancer 126 (2) (2019)
Jennifer N Cash, Sarah Urata, Sheng Li, Sandeep K Ravala, Larisa V Avramova, Michael D Shost, Jorge Silvio Gutkind, John Joseph Grubb Tesmer, Michael A Cianfrocco
Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold. Science advances 5 (10) (2019)
Ramiro Iglesias-Bartolome, Akihiko Uchiyama, Napoleone Ferrara, Loreto Abusleme, Stephen R Brooks, Juan Luis Callejas-Valera, Dean Edwards, Colleen L Doçi, Marie-Liesse Asselin-Labat, Mark W Onaitis, Niki M Moutsopoulos, Jorge Silvio Gutkind, Maria I Morasso
Transcriptional signature primes human oral mucosa for rapid wound healing. Science translational medicine 10 (451) (2019)
Suvi Annala, Xiaodong Feng, Naveen Shridhar, Funda Eryilmaz, Julian Patt, JuHee Yang, Eva M Pfeil, Rodolfo Daniel Cervantes-Villagrana, Asuka Inoue, Felix Häberlein, Tanja Slodczyk, Raphael Reher, Stefan Kehraus, Stefania Monteleone, Ramona Schrage, Nina Heycke, Ulrike Rick, Sandra Engel, Alexander Pfeifer, Peter Kolb, Gabriele König, Moritz Bünemann, Thomas Tüting, José Vázquez-Prado, Jorge Silvio Gutkind, Evelyn Gaffal, Evi Kostenis
Direct targeting of Gαq and Gα11 oncoproteins in cancer cells. Science signaling 12 (573) (2019)
Sumit J Bandekar, Nadia Arang, Ena S Tully, Brittany A Tang, Brenna L Barton, Sheng Li, Jorge Silvio Gutkind, John Joseph Grubb Tesmer
Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential. Science signaling 12 (569) (2019)
Morgan O'Hayre, Kelsie Eichel, Silvia Avino, Xuefeng Zhao, Dana J Steffen, Xiaodong Feng, Kouki Kawakami, Junken Aoki, Karen Messer, Roger Sunahara, Asuka Inoue, Mark Von Zastrow, Jorge Silvio Gutkind
Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK. Science signaling 10 (484) (2017)

Jorge Silvio Gutkind.css-eqlu8i{font-size:small;padding-left:4px;} (J S Gutkind, J Silvio Gutkind)

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Jorge Silvio Gutkind (J S Gutkind, J Silvio Gutkind)