Latitude continues to be significantly associated with the prevalence of multiple sclerosis: an updated meta-analysis.

Steve Simpson YapWendy WangPeter OtahalLeigh BlizzardIngrid A F van der MeiBruce V Taylor

Published in: Journal of neurology, neurosurgery, and psychiatry (2019)

This new meta-analysis confirms that MS prevalence is still strongly positively associated with increasing latitude and that the gradient is increasing, suggesting that potentially modifiable environmental factors, such as sun exposure, are still strongly associated with MS risk.

Keyphrases

multiple sclerosis
systematic review
meta analyses
mass spectrometry
risk factors
ms ms
white matter
case control
randomized controlled trial