Spatial Relation Between White Matter Hyperintensities and Incident Lacunes of Presumed Vascular Origin: A 14-Year Follow-Up Study.
Fang YiMengfei CaiMina A JacobJosé MarquesDavid Gordon NorrisMarco DueringAnil M TuladharFrank-Erik de LeeuwPublished in: Stroke (2022)
The 2 different distribution patterns of lacunes regarding their relation to WMH may suggest distinct underlying mechanisms, one of which may be more closely linked to a similar pathophysiology as that of WMH. The longitudinal relation between WMH and lacunes further supports plausible shared mechanisms between the 2 key markers.