Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.
David H SpencerMolly C SchroederMichele O'LaughlinRoxanne WilsonSandra MacMillanAndrew BohannonScott KruchowskiJohn GarzaFeiyu DuAndrew E O HughesJosh RobinsonEmma HughesSharon E HeathJack D BatyJulie NeidichMatthew J ChristopherMeagan A JacobyGeoffrey L UyRobert S FultonChristopher A MillerJacqueline E PaytonDaniel C LinkMatthew J WalterPeter WesterveltJohn F DiPersioTimothy J LeyDavid H SpencerPublished in: The New England journal of medicine (2021)
In our study, we found that whole-genome sequencing provided rapid and accurate genomic profiling in patients with AML or MDS. Such sequencing also provided a greater diagnostic yield than conventional cytogenetic analysis and more efficient risk stratification on the basis of standard risk categories. (Funded by the Siteman Cancer Research Fund and others.).