Role of the PhoPQ two-component regulatory system in the β-lactam resistance of Stenotrophomonas maltophilia.

Hsin-Hui HuangBo-Kuan WuLi-Hua LiYi-Tsung LinTsuey-Ching Yang

Published in: The Journal of antimicrobial chemotherapy (2021)

The PhoPQ TCS is activated to some extent in physiologically grown S. maltophilia. Inactivation of phoPQ attenuates the expression of mltD1 and slt, and increases β-lactam influx, both synergically contributing to β-lactam resistance compromise.

Keyphrases

gram negative
poor prognosis
transcription factor
multidrug resistant
long non coding rna