The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE".
Peter SavasZhi Ling TeoChristophe M LefèvreChristoffer FlensburgFranco CaramiaKathryn AlsopMariam MansourPrudence A FrancisHeather A ThorneMaria Joao SilvaNnennaya KanuMichelle DietzenAndrew RowanMaik KschischoStephen B FoxDavid D BowtellSarah-Jane DawsonTerence P SpeedCharles SwantonSherene LoiPublished in: PLoS medicine (2016)
This study highlights various mechanisms that shape the genome of metastatic breast cancer and the value of studying advanced disease in detail. Treatment drives significant genomic heterogeneity in breast cancers which has implications for disease monitoring and treatment selection in the personalised medicine paradigm.